Vaccines: Pregnancy & Children

Transplacental Transmission of the COVID-19 Vaccine mRNA: Evidence from
Placental, Maternal and Cord Blood Analyses Post-Vaccination

A pre-print

Amongst 283,422 previously unvaccinated children and 132,462 children who had received a first vaccine dose, COVID-19-related outcomes were too rare to allow IRRs to be estimated precisely. A&E attendance and unplanned hospitalisation were slightly higher after first vaccination (IRRs versus no vaccination 1.05 (1.01-1.10) and 1.10 (0.95-1.26) respectively) but slightly lower after second vaccination (IRRs versus first dose 0.95 (0.86-1.05) and 0.78 (0.56-1.08) respectively). There were no COVID-19-related deaths in any group. Fewer than seven (exact number redacted) COVID-19-related critical care admissions occurred in the adolescent first dose vs unvaccinated cohort. Among both adolescents and children, myocarditis and pericarditis were documented only in the vaccinated groups, with rates of 27 and 10 cases/million after first and second doses respectively.

Conclusion BNT162b2 vaccination in adolescents reduced COVID-19 A&E attendance and hospitalisation, although these outcomes were rare. Protection against positive SARS-CoV-2 tests was transient.

Dr Clare Craig talks about the pfizer vaccine trials in children

Was Vaccinating Children Against Covid a Mistake?  Article in the ‘Unheard’

“Firm data on hospitalisation due to Covid-19 vaccination is hard to come by, but in the US the CDC V-Safe monitoring system reports that between 1 in 5,000 and 1 in 2,500 children (depending on age group and dose) were hospitalised in the seven days after being vaccinated. Applying this to the 1.2 million fully vaccinated children in the Lancet study would suggest between 240 and 480 additional non-Covid hospitalisations, dwarfing the estimated reduction in hospitalisation for Covid-19. 
By focusing only on hospitalisation, and ignoring other short and long-term side effects, the risk-benefit ratio does not come close to justifying the rollout of Covid-19 vaccination to healthy 5 to 15-year-olds. Even for those in a clinical risk group, the benefit-risk ratio is at best marginal. 

By its own logic, the data in the Lancet paper suggests that rolling out the vaccine to all children over the age of 5 was a policy error. If anything it led to more, not less hospitalisation.”

Determinants of COVID-19 vaccine-induced myocarditis

Conclusion:

COVID-19 vaccination is strongly associated with a serious adverse safety signal of myocarditis, particularly in children and young adults resulting in hospitalization and death. Further investigation into the underlying mechanisms of COVID-19 vaccine-induced myocarditis is imperative to create effective mitigation strategies and ensure the safety of COVID-19 vaccination programs across populations.
Vaccine Generated Spike in the Blood of Children with Myocarditis

Receipt of BNT162b2 Vaccine and COVID-19 Ambulatory Visits in US Children Younger Than 5 Years

The approved three-dose schedule of Pfizer Covid vaccines for children under 5 did not reduce Covid-related medical visits.