Transfected SARS-CoV-2 spike DNA for mammalian cell expression inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells and increases cancer cell viability after chemotherapy exposure
The suppressive effect of SARS-CoV-2 spike on p53-dependent gene activation provides a potential molecular mechanism by which SARS-CoV-2 infection may impact tumorigenesis, tumor progression and chemotherapy sensitivity. In fact, cisplatin-treated tumor cells expressing spike were found to have increased cell viability as compared to control cells.
Impact of detection of bacterial endotoxin in menstrual effluent on the pregnancy rate in in vitro fertilization and embryo transfer
Endotoxins in covid19 vaccines may contribute to infertility.
Conclusion “Bacterial endotoxin was detectable in menstrual effluent from infertile women. The pregnancy rate after IVF-ET was significantly higher in women with an endotoxin level of </=200 pg/mL than in women with an endotoxin level of >200.0 pg/mL.”
Read more in Geoff Pain’s substack HERE
Escherichia coli contamination of menstrual blood and effect of bacterial endotoxin on endometriosis
Endotoxins may contribute to endometriosis in vaccinated women
“Our results suggest that compared with control women, higher colony formation of Escherichia coli in menstrual blood and endotoxin levels in menstrual fluid and peritoneal fluid in women with endometriosis may promote Toll-like receptor 4–mediated growth of endometriosis.”
Investigating trends in those who experience menstrual bleeding changes after SARS-CoV-2 vaccination
“Among respondents who typically do not menstruate, 71% of people on long-acting reversible contraceptives, 39% of people on gender-affirming hormones, and 66% of postmenopausal people reported breakthrough bleeding.”
SARS-CoV-2 spike S2 subunit inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells
Pre-Print from Brown University. How spike protein could potentially promote cancer by interfering with anti-cancer activities by blocking a cancer suppressor gene known as p53.
The gene—the most commonly affected by cancer—stops cancer cell growth and encourages DNA repair.
VEXAS syndrome following COVID-19 mRNA vaccination
Vexas causes blood clots and fever. It has a genetic element. Read more about this condition here
ANCA-associated glomerulonephritis and lupus nephritis following COVID-19 vaccination: a case report and literature review
ANCA-associated glomerulonephritis and lupus nephritis (kideny injuries) following COVID-19 vaccination – “We provide a literature review about kidney damage related to ANCA vasculitis after COVID-19 vaccine, aiming for a better understanding of the pathophysiological mechanism of kidney injury, its presentation, and treatment.”
COVID-19 vaccines and adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals
Data from 99 million individuals is studied, revealing increases in cardiovascular and neurological injuries. Myocarditis, a heart muscle inflammation, notably increased after the second Moderna vaccine dose. The same vaccine also showed a rise in pericarditis cases. – The AstraZeneca vaccine was significantly associated with Guillain-Barre syndrome, a neurological disorder, and a 3x increase in cerebral venous sinus thrombosis, a rare brain blood clot. – Both viral-vector and mRNA vaccines indicated potential risks for transverse myelitis and acute disseminated encephalomyelitis, affecting the spinal cord and brain respectively.
Reactivation of previously controlled Vogt–Koyanagi–Harada disease more than 46 years following COVID-19 vaccination: a case study
“A 59-year-old woman presented to the Imaizumi Eye Hospital with blurred vision in both eyes” “VKH disease can recur a very long time after initial treatment (up to 46 years later according to the present case). Thus, ophthalmologists must remain vigilant of this possibility considering the increasing number of people developing COVID-19 and receiving COVID-19 vaccinations. Furthermore, recurrence should be considered if a patient has ocular symptoms and a history of treatment for VKH disease.”
Treatment refractory acute necrotizing myelitis after COVID-19 vaccine injection: a case report“
Conclusion:
Post-vaccination necrotizing myelitis is a lethal medical situation requiring intensive and emergent neurosurgical vigilance. Early clinical diagnosis in the beginning and full neurosurgical-neurological treatment armamentarium options are cornerstones of treatment paradigms. Salvage treatment options such as extensive laminectomy may play a life-saving role in treatment refractory cases of acute necrotizing myelitis.”
Spontaneous spinal epidural haematoma following COVID-19 vaccination: a case report
Case presentation:
An 80-year-old male who received his first shot of the COVID-19 vaccine had developed COVID-19 pneumonia, weakness, and sensory problems in his legs followed by sphincter incontinence within 5 days period. MRI showed a spontaneous epidural spinal epidural haematoma (SSEDH) in T10–L1. He underwent laminectomy and haematoma evacuation. One month follow-up showed no clinical improvement.
Immediate adverse reactions following COVID-19 vaccination among 16-6Hypophysitis after COVID-19 vaccination in a patient with Rathke’s cleft cyst: A case report-year-old Danish citizens
ABSTRACT
With the widespread vaccination of COVID-19 vaccine, a few cases have been reported that COVID-19 vaccine may cause endocrine disorders. A 59-y-old man presented with a loss of appetite after the first COVID-19 vaccination, which resolved spontaneously after 3 d. After the second COVID-19 vaccination, the symptoms including the loss of appetite, nausea, and vomiting reappeared and worsened along with loss of vision. He was found to have severe hyponatremia, and further investigations revealed secondary adrenal insufficiency, secondary hypothyroidism and Rathke’s cleft cyst. The patient responded well to glucocorticoid and levothyroxine supplementation, and at 1-y follow-up the patient developed hypogonadism. We hypothesize that hypophysitis is probably induced by COVID-19 vaccine and report the rare but serious adverse reactions for early recognition and intervention.
“The many alterations in the vaccine mRNA hide the mRNA from cellular defenses and promote a longer biological half-life and high production of spike protein. However, the immune response to the vaccine is very different from that to a SARS-CoV-2 infection. In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell’s palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. We show evidence from the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines questions them as positive contributors to public health.”
PF4 activates the c-Mpl-Jak2 pathway in platelets
Scientists explain the mechanism causing VITT – deadly blood clots after some COVID19 vaccines
Read an article about this research paper HERE
“Anticardiolipin and D-dimer were significantly higher in recipients of mRNA vaccines compared to viral vector vaccines (p<0.05). This study discovered that recipients of the COVID-19 immunization have a higher risk of developing antiphospholipid syndrome due to increased anticardiolipin. If disseminated intravascular coagulations is present and its complications are not adequately handled, this could become more serious.”
Results: The NEURO-COVAX-cohort included 19.108 vaccinated people: 15.368 with BNT162b2, 2077 with mRNA-1273, 1651 with ChAdOx1nCov-19, and 12 with Ad26.COV2.S who were subsequently excluded. Approximately 31.2% of our sample developed post-vaccination neurological complications, particularly with ChAdOx1nCov-19. A vulnerable clinical profile emerged, where over 40% of the symptomatic people showed comorbidities in their clinical histories
From the Italian Journal of Rheumatology. “We read with interest the article by Camargo-Coronel et al. reporting on a systematic review of patients with idiopathic, inflammatory myopathy developing after anti-SARS-CoV-2 vaccinations.”
We present a case of a 24-year-old male without preexisting conditions or family history of autoimmune disorders, presenting with SLE following the first dose of the SARS-CoV-2 Pfizer-BioNTech mRNA vaccine.
MC are stimulated not only by allergens, but also many other triggers including some from the ANS that can affect MC release of neurosensitizing, proinflammatory and vasoactive mediators. Hence MC may be able to regulate homeostatic functions that appear to be dysfunctional in many conditions, such as postural orthostatic tachycardia syndrome (POTS), autism spectrum disorder (ASD), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long-COVID syndrome. The evidence indicates that there is a possible association between these conditions and diseases associated with mast cell activation,”
The results obtained for mitochondria, lipid droplets, cytoplasm may suggest that COVID-19 mRNA (Pfizer/BioNT) vaccine reprograms immune responses. The observed alterations in biochemical profiles upon incubation with COVID-19 mRNA in the specific organelles of the glial cells are similar to those we observe for brain cancer vs grade of aggressiveness.
“New symptoms after SARS-CoV-2 vaccination must be taken seriously and require thorough investigation. The earlier complications of SARS-CoV-2 vaccination are detected, the earlier treatment can be started and the more favorable the outcome.”